disulfiram

Synonyms: "tetraethylthiuram disulfide", "antabuse", "teturam", "bis(diethylthiocarbamoyl) disulfide", "Esperal", "Anticol", "Alcophobin", "Antabus", "TETD", "Dicupral", "Exhorran", "Hoca", "Ethyldithiurame", "Teturamin", "Tetraetil", "Contralin", "Tetradine", "Antivitium", "Abstensil", "Antietanol", "Antaethyl", "Aversan", "Abstinil", "Refusal", "Krotenal", "Averzan", "Antetil", "Antetan", "Abstinyl", "Cronetal", "Antikol", "Antietil", "Antalcol", "Antadix", "Etabus", "Ethyl tuads", "Ethyl Thiurad", "Ethyl Thiram", "Ethyl Tuex", "Disulfuram", "Contrapot", "Antiaethan", "Stopetyl", "Disulfan", "Antaenyl", "Thiuranide", "Ephorran", "Antae".

Source: Disulfiram is a drug used to treat alcoholism.

Identifiers:

IUPAC Name: diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate
CAS Number: 97-77-8
PubChem ID: 3117
InChiKey: AUZONCFQVSMFAP-UHFFFAOYSA-N
Canonical SMILES: CCN(CC)C(=S)SSC(=S)N(CC)CC

Structural Properties:

Molecular Formula: C₁₀H₂₀N₂S₄
Molecular Weight: 296.524

Pharmacophore Features:

Number of bond donors: 0
Number of bond acceptors: 4
Number of atoms different from hydrogen: 16

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3D structure (.sdf)
3D structure (.mol2)
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Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors

Cavalleri, A., Polatti, F. and Bolis, P.F., 1978. Acute effects of tetraethyltiuram disulfide on serum levels of hypophyseal hormones in humans. Scandinavian journal of work, environment & health, pp.66-72. URL: https://www.jstor.org/stable/40964693.
Christensen, J., Wase, A.W. and Van Dyke, J.H., 1955. Tetraethylthiuram disulphide (disulfiram) and thyroid activity. Acta pharmacologica et toxicologica, 11(2), pp.163-167. DOI: 10.1111/j.1600-0773.1955.tb00215.x . URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0773.1955.tb00215.xFuller, R.W. and Snoddy, H., 1968. Inhibition by disulfiram of the accelerated turnover of catecholamines in the adrenal glands of exercised rats. Journal of Pharmacy and Pharmacology, 20(2), pp.156-157. DOI: 10.1111/j.2042-7158.1968.tb09710.x . URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.2042-7158.1968.tb09710.x.
Telkka, A. and Kivalo, E., 1958. The effect of tetraethylthiuram disulphide (Disulfiram, Antabuse) on the thyroid of the rat. Acta endocrinologica, 27(1), pp.85-88. DOI: 10.1530/acta.0.0270085. URL: https://eje.bioscientifica.com/view/journals/eje/27/1/acta_27_1_008.xmlWase, A.W. and Christensen, 1954. Antithyroid Action of Tetraethylthiuram disulfide. Journal of Biological Chemistry. pp. 75-78. URL: https://pdfs.semanticscholar.org/dab6/ c8b7afdc24b622bc278c736b1c5ba2f60cfd.pdf