flutamide

Synonyms: "2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide", "Cebatrol, veterinary", "Sch 13521", "Flutamin", "Sch-13521", "4'-Nitro-3'-trifluoromethylisobutyranilide", "2-Methyl-N-(4-nitro-3-[trifluoromethyl]phenyl)propanamide", "flutamide", "Niftolide", "Eulexin", "Niftholide", "NFBA", "niftolid", "Flutamidum", "Drogenil", "Flutamida".

Source: Flutamide is an anticancer drug.

Identifiers:

IUPAC Name: 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
CAS Number: 13311-84-7
PubChem ID: 3397
InChiKey: MKXKFYHWDHIYRV-UHFFFAOYSA-N
Canonical SMILES: CC(C)C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F

Structural Properties:

Molecular Formula: C₁₁H₁₁F₃N₂O₃
Molecular Weight: 276.215

Pharmacophore Features:

Number of bond donors: 1
Number of bond acceptors: 6
Number of atoms different from hydrogen: 19

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3D structure (.sdf)
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3D structure (.pdb)
3D structure (.pdbqt)

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Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors

Tamura H, Ishimoto Y, Fujikawa T, Aoyama H, Yoshikawa H, Akamatsu M. 2006. Structural basis for androgen receptor agonists and antagonists: Interaction of SPEED 98-listed chemicals and related compounds with the androgen receptor based on an in vitro reporter gene assay and 3D-QSAR. Bioorg Med Chem 14(21):7160-7174. DOI: 10.1016/j.bmc.2006.06.064. URL: https://www.sciencedirect.com/science/article/pii/S0968089606005396.