decamethylcyclopentasiloxane

Synonyms: "decamethylcyclophentasiloxane", "NUC silicone VS 7158", "Dow corning 345", "cyclomethicone", "silicon SF 1202", "cyclic dimethylsiloxane pentamer", "2,2,4,4,6,6,8,8,10,10-decamethyl-1,3,5,7,9,2,4,6,8,10-pentaoxapentasilecane".

Source: decamethylcyclopentasiloxane is used in the formulation of consumer products, such as cosmetics and cleaning agents, as well as an industrial intermediate.

Identifiers:

IUPAC Name: 2,2,4,4,6,6,8,8,10,10-decamethyl-1,3,5,7,9,2,4,6,8,10-pentaoxapentasilecane
CAS Number: 541-02-6
PubChem ID: 10913
InChiKey: XMSXQFUHVRWGNA-UHFFFAOYSA-N
Canonical SMILES: C[Si]1(O[Si](O[Si](O[Si](O[Si](O1)(C)C)(C)C)(C)C)(C)C)C

Structural Properties:

Molecular Formula: C₁₀H₃₀O₅Si₅
Molecular Weight: 370.770

Pharmacophore Features:

Number of bond donors: 0
Number of bond acceptors: 5
Number of atoms different from hydrogen: 20

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Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors

Burns-Naas LA, Mast RW, Klykken PC, McCay JA, White KL, Jr., Mann PC, Naas DJ. 1998. Toxicology and humoral immunity assessment of decamethylcyclopentasiloxane (D5) following a 1-month whole body inhalation exposure in Fischer 344 rats. Toxicol Sci 43(1):28-38. DOI: 10.1006/toxs.1998.2442. URL: https://www.sciencedirect.com/science/article/pii/S1096608098924428.
Burns-Naas LA, Mast RW, Meeks RG, Mann PC, Thevenaz P. 1998. Inhalation toxicology of decamethylcyclopentasiloxane (D5) following a 3-month nose-only exposure in Fischer 344 rats. Toxicol Sci 43(2):230-240. DOI: 10.1006/toxs.1998.2441. URL: http://www.sciencedirect.com/science/article/pii/S1096608098924416.
Siddiqui WH, Stump DG, Reynolds VL, Plotzke KP, Holson JF, Meeks RG. 2007. A two-generation reproductive toxicity study of decamethylcyclopentasiloxane (D5) in rats exposed by whole-body vapor inhalation. Reprod Toxicol 23(2):216-225. DOI: 10.1016/j.reprotox.2006.11.006. URL: https://www.sciencedirect.com/science/article/pii/S0890623806002747.