2,4-dimethoxy-4'-hydroxybenzophenone

Synonyms: "2,4-dimethoxy-4'-hydroxybenzophenone", "(2,4-dimethoxyphenyl)(4-hydroxyphenyl)methanone", "4'-hydroxy-2,4-dimethoxybenzophenone", "4-(2,4-dimethoxybenzoyl)phenol", "2,4-dimethoxy-4-hydroxybenzophenone", "(2,4-dimethoxyphenyl)-(4-hydroxyphenyl)methanone","2,4-dimethoxyphenyl 4-hydroxyphenyl ketone".

Source: 2,4-dimethoxy-4 -hydroxybenzophenone is obtained by Friedel?Crafts reaction.

Identifiers:

IUPAC Name: (2,4-dimethoxyphenyl)-(4-hydroxyphenyl)methanone
CAS Number: 41351-30-8
PubChem ID: 688628
InChiKey: QEHRETCJMLQPCR-UHFFFAOYSA-N
Canonical SMILES: COC1=CC(=C(C=C1)C(=O)C2=CC=C(C=C2)O)OC

Structural Properties:

Molecular Formula: C₁₅H₁₄O₄
Molecular Weight: 258.273

Pharmacophore Features:

Number of bond donors: 1
Number of bond acceptors: 4
Number of atoms different from hydrogen: 19

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3D structure (.sdf)
3D structure (.mol2)
3D structure (.pdb)
3D structure (.pdbqt)

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Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors

Kawamura Y, Mutsuga M, Kato T, Iida M, Tanamoto K. 2005. Estrogenic and anti-androgenic activities of benzophenones in human estrogen and androgen receptor mediated mammalian reporter gene assays. Journal of Health Science 51(1):48-54. DOI: 10.1248/jhs.51.48. URL: https://www.jstage.jst.go.jp/article/jhs/51/1/51_1_48/_article.
Kawamura Y, Ogawa Y, Nishimura T, Kikuchi Y, Nishikawa J, Nishihara T, Tanamoto K. 2003. Estrogenic activities of UV stabilizers used in food contact plastics and benzophenone derivatives tested by the yeast two-hybrid assay. Journal of Health Science 49(3):205-212. DOI: 10.1248/jhs.49.205. URL: https://www.jstage.jst.go.jp/article/jhs/49/3/49_3_205/_article.