forskolin

Synonyms: "colforsin", "coleonol", "boforsin"

Source: forskolin is a chemical found in the roots of the plant Plectranthus barbatus (Coleus forskohlii), which is used to treat high blood pressure and heart failure, asthma, allergies, eczema, psoriasis, obesity, dysmenorrhea, irritable bowel syndrome and urinary tract infections, among others.

Identifiers:

IUPAC Name: [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl]acetate
CAS Number: 66575-29-9
PubChem ID: 47936
InChiKey: OHCQJHSOBUTRHG-KGGHGJDLSA-N
Canonical SMILES: CC(=O)OC1C(C2C(CCC(C2(C3(C1(OC(CC3=O)(C)C=C)C)O)C)O)(C)C)O

Structural Properties:

Molecular Formula: C₂₂H₃₄O₇
Molecular Weight: 410.501

Pharmacophore Features:

Number of bond donors: 3
Number of bond acceptors: 6
Number of atoms different from hydrogen: 29

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2D structure (.sdf)
3D structure (.sdf)
3D structure (.mol2)
3D structure (.pdb)
3D structure (.pdbqt)

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Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors

Sanderson JT, Boerma J, Lansbergen GW, van den Berg M. 2002. Induction and inhibition of aromatase (CYP19) activity by various classes of pesticides in H295R human adrenocortical carcinoma cells. Toxicol Appl Pharmacol 182(1):44-54.