1,2,7,8-tetrachlorodibenzofuran

Synonyms: "1,2,7,8-TCDF", "PCDF 61"

Source: 1,2,7,8-tetrachlorodibenzofuran is one of the polychlorinated dibenzofurans (PCDFs), which are ubiquitous environmental contaminants, usually formed as byproducts of the production and use of polychlorinated biphenyls (PCBs).

Identifiers:

IUPAC Name: 1,2,7,8-tetrachlorodibenzofuran
CAS Number: 58802-20-3
PubChem ID: 42844
InChiKey: JODWPAQNABOHDG-UHFFFAOYSA-N
Canonical SMILES: C1=CC(=C(C2=C1OC3=CC(=C(C=C32)Cl)Cl)Cl)Cl

Structural Properties:

Molecular Formula: C₁₂H₄Cl₄O
Molecular Weight: 305.972

Pharmacophore Features:

Number of bond donors: 0
Number of bond acceptors: 0
Number of atoms different from hydrogen: 17

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2D structure (.sdf)
3D structure (.sdf)
3D structure (.mol2)
3D structure (.pdb)
3D structure (.pdbqt)

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Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors

Harper N, Wang X, Liu H, Safe S. 1994. Inhibition of estrogen-induced progesterone receptor in MCF-7 human breast cancer cells by aryl hydrocarbon (Ah) receptor agonists. Molecular & Cellular Endocrinology 104(1):47-55.

Liu H, Biegel L, Narasimhan TR, Rowlands C, Safe S. 1992. Inhibition of insulin-like growth factor-I responses in MCF-7 cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Mol Cell Endocrinol 87(1-3):19-28.