heptachlor

Synonyms: "Aahepta,"heptachlorane", "heptamul", "3-chlorochlordene", "rhodiachlor", "agroceres", "heptagran", "drinox"

Source: heptachlor is an organochlorine cyclodiene insecticide.

Identifiers:

IUPAC Name: 1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methano-1H-indene
CAS Number: 76-44-8
PubChem ID: 3589
InChiKey: FRCCEHPWNOQAEU-UHFFFAOYSA-N
Canonical SMILES: C1=CC(C2C1C3(C(=C(C2(C3(Cl)Cl)Cl)Cl)Cl)Cl)Cl

Structural Properties:

Molecular Formula: C₁₀H₅Cl₇
Molecular Weight: 373.318

Pharmacophore Features:

Number of bond donors: 0
Number of bond acceptors: 0
Number of atoms different from hydrogen: 17

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Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors

Abalis IM, Eldefrawi ME, Eldefrawi AT. 1985. High-affinity stereospecific binding of cyclodiene insecticides and gamma-hexachlorocyclohexane to gamma-aminobutyric acid receptors of rat brain. Pesticide Biochemistry & Physiology 24(1):95-102.

Amita Rani BE, Krishnakumari MK. 1995. Prenatal toxicity of heptachlor in albino rats. Pharmacology & Toxicology 76(2):112-114.

Haake J, Kelley M, Keys B, Safe S. 1987. The effects of organochlorine pesticides as inducers of testosterone and benzo[a]pyrene hydroxylases. Gen Pharmacol 18(2):165-169.

Kojima H, Katsura E, Takeuchi S, Niiyama K, Kobayashi K. 2004. Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ Health Perspect 112(5):524-531.

Oduma JA, Wango EO, Oduorokelo D, Makawiti DW, Odongo H. 1995. In vivo and in vitro effects of graded doses of the pesticide heptachlor on female sex steroid hormone production in rats. Comparative Biochemistry & Physiology C: Comparative Pharmacology & Toxicology 111(2):191-196.