toxaphene

Synonyms: "1,4,5,6,7,7-hexachloro-3,3-bis(chloromethyl)-2-methylidenebicyclo[2.2.1]heptane"

Source: toxaphene is an insecticide and acaricide.

Identifiers:

IUPAC Name: 1,4,5,6,7,7-hexachloro-3,3-bis(chloromethyl)-2-methylidenebicyclo[2.2.1]heptane
CAS Number: 8001-35-2
PubChem ID: 5284469
InChiKey: OEJNXTAZZBRGDN-UHFFFAOYSA-N
Canonical SMILES: C=C1C(C2(C(C(C1(C2(Cl)Cl)Cl)Cl)Cl)Cl)(CCl)CCl

Structural Properties:

Molecular Formula: C₁₀H8Cl8
Molecular Weight: 411.795

Pharmacophore Features:

Number of bond donors: 0
Number of bond acceptors: 0
Number of atoms different from hydrogen: 18

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Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors

Haake J, Kelley M, Keys B, Safe S. 1987. The effects of organochlorine pesticides as inducers of testosterone and benzo[a]pyrene hydroxylases. Gen Pharmacol 18(2):165-169.

Hurst JG, Newcomer WS, Morrison JA. 1974. Some effects of DDT, Toxaphene and Polychlorinated Biphenyl on thyroid function in Bobwhite Quail. Poult Sci 53(1):125-133.

Scippo ML, Argiris C, Van De Weerdt C, Muller M, Willemsen P, Martial J, Maghuin-Rogister G. 2004. Recombinant human estrogen, androgen and progesterone receptors for detection of potential endocrine disruptors. Anal Bioanal Chem 378(3):664-669.

Soto AM, Sonnenschein C, Chung KL, Fernandez MF, Olea N, Serrano FO. 1995. The E-SCREEN assay as a tool to identify estrogens: An update on estrogenic environmental pollutants. Environ Health Perspect 103 (Suppl. 7):113-122.

Waritz RS, Steinberg M, Kinoshita FK, Kelly CM, Richter WR. 1996. Thyroid function and thyroid tumors in toxaphene-treated rats. Regul Toxicol Pharmacol 24(2 Part 1):184-192.