butyl paraben

Synonyms: "butylparaben", "butyl 4-hydroxybenzoate", "butyl paraben", "butyl p-hydroxybenzoate", "n-butyl p-hydroxybenzoate", "butoben", "nipabutyl", "butyl chemosept"

Source: butyl Paraben is an antimicrobial agent used in cosmetic products.

Identifiers:

IUPAC Name: butyl 4-hydroxybenzoate
CAS Number: 94-26-8
PubChem ID: 7184
InChiKey: QFOHBWFCKVYLES-UHFFFAOYSA-N
Canonical SMILES: CCCCOC(=O)C1=CC=C(C=C1)O

Structural Properties:

Molecular Formula: C11H14O3
Molecular Weight: 194,2271

Pharmacophore Features:

Number of bond donors: 1
Number of bond acceptors: 2
Number of atoms different from hydrogen: 14

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Toxicological Information

ACToR (Aggregated Computational Toxicology Resource)

HSDB (Hazardous Substances Data Bank)

CCRIS (Chemical Carcinogenesis Research Information System)

CTD (Comparative Toxicogenomics Database)

Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors


Boberg J, Metzdorff S, Wortziger R, Axelstad M, Brokken L, Vinggaard AM, Dalgaard M, Nellemann C. 2008. Impact of diisobutyl phthalate and other PPAR agonists on steroidogenesis and plasma insulin and leptin levels in fetal rats. Toxicology 250(2-3):75-81.
Chen JG, Ahn KC, Gee NA, Gee SJ, Hammock BD, Lasley BL. 2007. Antiandrogenic properties of parabens and other phenolic containing small molecules in personal care products. Toxicol Appl Pharmacol 221(3):278-284.
Gomez E, Pillon A, Fenet H, Rosain D, Duchesne MJ, Nicolas JC, Balaguer P, Casellas C. 2005. Estrogenic activity of cosmetic components in reporter cell lines: parabens, UV screens, and musks. J Toxicol Environ Health A 68(4):239-251.
Song BL, Peng DR, Li HY, Zhang GH, Zhang J, Li KL, Zhao YQ. 1991. Evaluation of the effect of butyl p-hydroxybenzoate on the proteolytic activity and membrane function of human spermatozoa. J Reprod Fertil 91(2):435-440.
Taxvig C, Vinggaard AM, Hass U, Axelstad M, Boberg J, Hansen PR, Frederiksen H, Nellemann C. 2008. Do parabens have the ability to interfere with steroidogenesis? Toxicol Sci 106(1):206-213.

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