flutamide

Synonyms: "2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide", "Cebatrol, veterinary", "Sch 13521", "Flutamin", "Sch-13521", "4'-Nitro-3'-trifluoromethylisobutyranilide", "2-Methyl-N-(4-nitro-3-[trifluoromethyl]phenyl)propanamide", "flutamide", "Niftolide", "Eulexin", "Niftholide", "NFBA", "niftolid", "Flutamidum", "Drogenil", "Flutamida".

Source: Flutamide is an anticancer drug.

Identifiers:

IUPAC Name: 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
CAS Number: 13311-84-7
PubChem ID: 3397
InChiKey: MKXKFYHWDHIYRV-UHFFFAOYSA-N
Canonical SMILES: CC(C)C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F

Structural Properties:

Molecular Formula: C11H11F3N2O3
Molecular Weight: 276.215

Pharmacophore Features:

Number of bond donors: 1
Number of bond acceptors: 6
Number of atoms different from hydrogen: 19

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Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors
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Tamura H, Ishimoto Y, Fujikawa T, Aoyama H, Yoshikawa H, Akamatsu M. 2006. Structural basis for androgen receptor agonists and antagonists: Interaction of SPEED 98-listed chemicals and related compounds with the androgen receptor based on an in vitro reporter gene assay and 3D-QSAR. Bioorg Med Chem 14(21):7160-7174. DOI: 10.1016/j.bmc.2006.06.064. URL: https://www.sciencedirect.com/science/article/pii/S0968089606005396.

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