2,4-dichlorophenoxyacetic acid

Synonyms: "hedonal", "(2,4-dichlorophenoxy)acetic acid", "agrotect", "fernesta", "fernimine", "netagrone", "tributon,"2,4-D"

Source: 2,4-dichlorophenoxyacetic acid is a systemic herbicide used post emergence for the control of broadleaf and grass weeds on crops, commercial and industrial areas, turf, forestry and waterways.

Identifiers:

IUPAC Name: 2-(2,4-dichlorophenoxy)acetic acid
CAS Number: 94-75-7
PubChem ID: 1486
InChiKey: OVSKIKFHRZPJSS-UHFFFAOYSA-N
Canonical SMILES: C1=CC(=C(C=C1Cl)Cl)OCC(=O)O

Structural Properties:

Molecular Formula: C8H6Cl2O3
Molecular Weight: 221.037

Pharmacophore Features:

Number of bond donors: 1
Number of bond acceptors: 3
Number of atoms different from hydrogen: 13

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Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors
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Cheney MA, Fiorillo R, Criddle RS. 1997. Herbicide and estrogen effects on the metabolic activity of Elliptio complanata measured by calorespirometry. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 118(2):159-164.

Florsheim WH, Velcoff SM. 1962. Some effects of 2,4-dichlorophenoxyacetic acid on thyroid function in the rat: Effects on iodine accumulation. Endocrinology 71(1):1-6.

Kanayama T, Kobayashi N, Mamiya S, Nakanishi T, Nishikawa J. 2005. Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor [gamma]/retinoid X receptor pathway. Mol Pharmacol 67(3):766-774.

Van den Berg KJ, van Raaij JAGM, Bragt PC, Notten WRF. 1991. Interactions of halogenated industrial chemicals with transthyretin and effects on thyroid hormone levels in vivo. Arch Toxicol 65(1):15-19.

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