aldrin

Synonyms: "aldocit", "aldrite", "aldrosol", "kortofin", "seedrin", "soilgrin", "tatuzinho", "aldron", "algran", "tipula",altox", "aldrex", "aldrine", "1,2,3,4,10,10-hexachloro-1,4,4a,5,8,8a-hexahydro-endo-1,4-exo-5,8-dimethanonaphthalene"

Source: aldrin is an organochlorine insecticide.

Identifiers:

IUPAC Name: 1,2,3,4,10,10-hexachloro-1,4,4a,5,8,8a-hexahydro-1,4:5,8-dimethanonaphthalene
CAS Number: 309-00-2
PubChem ID: 12310947
InChiKey: QBYJBZPUGVGKQQ-SJJAEHHWSA-N
Canonical SMILES: C1C2C=CC1C3C2C4(C(=C(C3(C4(Cl)Cl)Cl)Cl)Cl)Cl

Structural Properties:

Molecular Formula: C12H8Cl6
Molecular Weight: 364,91

Pharmacophore Features:

Number of bond donors: 0
Number of bond acceptors: 0
Number of atoms different from hydrogen: 18

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Toxicological Information

ACToR (Aggregated Computational Toxicology Resource)

HSDB (Hazardous Substances Data Bank)

CCRIS (Chemical Carcinogenesis Research Information System)

GENE-TOX

CTD (Comparative Toxicogenomics Database)

IRIS (Integrated Risk Information System)

ITER (International Toxicity Estimates for Risk)

Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors


Abalis IM, Eldefrawi ME, Eldefrawi AT. 1985. High-affinity stereospecific binding of cyclodiene insecticides and gamma-hexachlorocyclohexane to gamma-aminobutyric acid receptors of rat brain. Pesticide Biochemistry & Physiology 24(1):95-102.
Kojima H, Katsura E, Takeuchi S, Niiyama K, Kobayashi K. 2004. Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ Health Perspect 112(5):524-531.
Kuzan FB, Prahlad KV. 1975. The effects of 1,2,3,4,10,10-hexachloro-1,4,4a,5,8,8a-hexahydroxy endo, exo-5, 8-dimthionaphthalene (aldrin) and sodium ethylenebisdithiocarbomate (Nabam) on the chick. Poult Sci 54(4):1054-1064.
Scippo ML, Argiris C, Van De Weerdt C, Muller M, Willemsen P, Martial J, Maghuin-Rogister G. 2004. Recombinant human estrogen, androgen and progesterone receptors for detection of potential endocrine disruptors. Anal Bioanal Chem 378(3):664-669.

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Keywords


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