methyl tertiary butyl ether

Synonyms: "methyl tert-butyl ether", "tert-butyl methyl ether", "methyl t-butyl ether", "2-methoxy-2-methylpropane", "2-methoxy-2-methylpropane", "MTBE"

Source: 2-methoxy-2-methylpropane is used as an oxygenating agent in gasoline and has a detectable odor at low concentrations.


IUPAC Name: 2-methoxy-2-methylpropane
CAS Number: 1634-04-4
PubChem ID: 15413
Canonical SMILES: CC(C)(C)OC

Structural Properties:

Molecular Formula: C5H12O
Molecular Weight: 88.148

Pharmacophore Features:

Number of bond donors: 0
Number of bond acceptors: 1
Number of atoms different from hydrogen: 6


2D structure (.sdf)
3D structure (.sdf)
3D structure (.mol2)
3D structure (.pdb)
3D structure (.pdbqt)

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Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors

de Peyster A, Stanard B, Westover C. 2009. Effect of ETBE on reproductive steroids in male rats and rat Leydig cell cultures. Toxicol Lett 190(1):74-80.

Li DM, Han XD. 2006. Evaluation of toxicity of methyl tert-butyl ether (MTBE) on mouse spermatogenic cells in vitro. Toxicol Ind Health 22(7):291-299.

Williams TM, Borghoff SJ. 2000. Induction of testosterone biotransformation enzymes following oral administration of methyl tert-butyl ether to male Sprague-Dawley rats. Toxicol Sci 57(1):147-155.

Williams TM, Cattley RC, Borghoff SJ. 2000. Alterations in endocrine responses in male Sprague-Dawley rats following oral administration of methyl tert-butyl ether. Toxicol Sci 54(1):168-176.

Zheng G, Zhang W, Zhang Y, Chen Y, Liu M, Yao T, Yang Y, Zhao F, Li J, Huang C, Luo W, Chen J. 2009. [gamma]-Aminobutyric acid(A) (GABA(A)) receptor regulates ERK1/2 phosphorylation in rat hippocampus in high doses of methyl tert-butyl ether (MTBE)-induced impairment of spatial memory. Toxicol Appl Pharmacol 236(2):239-245, doi: 10.1016/j.taap.2009.01.004.

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