p-hydroxybenzoic acid

Synonyms: "4-hydroxybenzoic acid", "4-carboxyphenol", "p-salicylic acid", "p-carboxyphenol", "para-hydroxybenzoic acid", "p-hydroxybenzoic acid"

Source: 4-hydroxybenzoic acid is used to derive paraben, a common preservative used in the cosmetic industry.

Identifiers:

IUPAC Name: 4-hydroxybenzoic acid
CAS Number: 99-96-7
PubChem ID: 135
InChiKey: FJKROLUGYXJWQN-UHFFFAOYSA-N
Canonical SMILES: C1=CC(=CC=C1C(=O)O)O

Structural Properties:

Molecular Formula: C₇H₆O₃
Molecular Weight: 138.121

Pharmacophore Features:

Number of bond donors: 2
Number of bond acceptors: 3
Number of atoms different from hydrogen: 10

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2D structure (.sdf)
3D structure (.sdf)
3D structure (.mol2)
3D structure (.pdb)
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Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors

Lemini C, Silva G, Timossi C, Luque D, Valverde A, Gonzá,lez-Martí,nez M, Hernandez A, Rubio-Pó,o C, Chá,vez Lara B, Valenzuela F. 1997. Estrogenic effects of p-hydroxybenzoic acid in CD1 mice. Environ Res 75(2):130-134.

Peungvicha P, Thirawarapan SS, Watanabe H. 1998. Possible mechanism of hypoglycemic effect of 4-hydroxybenzoic acid, a constituent of Pandanus odorus root. Jpn J Pharmacol 78(3):395-398.

Pugazhendhi D, Pope GS, Darbre PD. 2005. Oestrogenic activity of p-hydroxybenzoic acid (common metabolite of paraben esters) and methylparaben in human breast cancer cell lines. J Appl Toxicol 25(4):301-319.