clotrimazole

Synonyms: "lotrimin", "mycelex", "canesten", "mycosporin", "clotrimazol", "mykosporin", "empecid", "gyne lotrimin", "gyne-lotrimin"

Source: clotrimazole is used to treat skin infections such as athlete's foot, jock itch, ringworm, and other fungal skin infections such as candidiasis.

Identifiers:

IUPAC Name: 1-[(2-chlorophenyl)-diphenylmethyl]imidazole
CAS Number: 23593-75-1
PubChem ID: 2812
InChiKey: VNFPBHJOKIVQEB-UHFFFAOYSA-N
Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4

Structural Properties:

Molecular Formula: C22H17ClN2
Molecular Weight: 344,837

Pharmacophore Features:

Number of bond donors: 0
Number of bond acceptors: 1
Number of atoms different from hydrogen: 25

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Toxicological Information

ACToR (Aggregated Computational Toxicology Resource)

HSDB (Hazardous Substances Data Bank)

CCRIS (Chemical Carcinogenesis Research Information System)

CTD (Comparative Toxicogenomics Database)

Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors


Lemaire G, Mnif W, Pascussi JM, Pillon A, Rabenoelina F, Fenet H, Gomez E, Casellas C, Nicolas JC, Cavailles V, Duchesne MJ, Balaguer P. 2006. Identification of new human pregnane X receptor ligands among pesticides using a stable reporter cell system. Toxicol Sci 91(2):501-509.

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