cytosine arabinoside

Synonyms: "cytarabine", "arabinosylcytosine", "arabinocytidine", "cytosar", "aracytidine", "cytarabin", "alexan", "depocyt"

Source: cytosine arabinoside is used alone or with other chemotherapy drugs to treat certain types of leukemia (cancer of the white blood cells).


IUPAC Name: 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
CAS Number: 147-94-4
PubChem ID: 6253
Canonical SMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O

Structural Properties:

Molecular Formula: C9H13N3O5
Molecular Weight: 243,2166

Pharmacophore Features:

Number of bond donors: 4
Number of bond acceptors: 7
Number of atoms different from hydrogen: 17


2D structure (.sdf)
3D structure (.sdf)
3D structure (.mol2)
3D structure (.pdb)
3D structure (.pdbqt)

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Toxicological Information

ACToR (Aggregated Computational Toxicology Resource)

HSDB (Hazardous Substances Data Bank)

CCRIS (Chemical Carcinogenesis Research Information System)


CTD (Comparative Toxicogenomics Database)

Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors

Gray LE Jr., Kavlok RJ, Ostby J, Ferrell J, Rogers J, Gray K. 1986. An evaluation of figure-eight maze activity and general behavioral development following prenatal exposure to forty chemicals: effects of cytosine arabinoside, dinocap, nitrofen, and vitamin A. Neurotoxicology 7(2):449-462.

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