cycloheximide

Synonyms: "cicloheximide", "kaken", "actidion", "actidone", "hizarocin", "neocycloheximide", "acti-aid"

Source: cycloheximide is an antibiotic which is very active against many molds, yeasts, and phytopathogenic fungi.

Identifiers:

IUPAC Name: 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione
CAS Number: 66-81-9
PubChem ID: 6197
InChiKey: YPHMISFOHDHNIV-FSZOTQKASA-N
Canonical SMILES: CC1CC(C(=O)C(C1)C(CC2CC(=O)NC(=O)C2)O)C

Structural Properties:

Molecular Formula: C15H23NO4
Molecular Weight: 281,3474

Pharmacophore Features:

Number of bond donors: 2
Number of bond acceptors: 4
Number of atoms different from hydrogen: 20

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Toxicological Information

ACToR (Aggregated Computational Toxicology Resource)

HSDB (Hazardous Substances Data Bank)

CCRIS (Chemical Carcinogenesis Research Information System)

GENE-TOX

CTD (Comparative Toxicogenomics Database)

Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors


Loukovaara M, Carson M, Adlercreutz H. 1995. Regulation of sex hormone-binding globulin secretion and gene expression by cycloheximide in vitro. J Steroid Biochem Mol Biol 54(3-4):141-146.

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