2,6-cis-diphenylhexamethylcyclotetrasiloxane

Synonyms: "2,6-diphenylhexamethylcyclotetrasiloxane", "2,2,4,6,6,8-hexamethyl-4,8-diphenylcyclotetrasiloxane", "quadrosilan", "cisobitan", "kabi 1774"

Source: 2,6-cis-diphenylhexamethylcyclotetrasiloxane is a drug for prostatic cancer.

Identifiers:

IUPAC Name: 2,2,4,6,6,8-hexamethyl-4,8-diphenyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane
CAS Number: 33204-76-1
PubChem ID: 20774
InChiKey: ZTQZMPQJXABFNC-UHFFFAOYSA-N
Canonical SMILES: C[Si]1(O[Si](O[Si](O[Si](O1)(C)C2=CC=CC=C2)(C)C)(C)C3=CC=CC=C3)C

Structural Properties:

Molecular Formula: C18H28O4Si4
Molecular Weight: 420,7545

Pharmacophore Features:

Number of bond donors: 0
Number of bond acceptors: 4
Number of atoms different from hydrogen: 26

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Toxicological Information

ACToR (Aggregated Computational Toxicology Resource)

Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors


Aire TA, Ikegwuonu FI, Heath EH. 1979. Effect of 2,6-cis-diphenylhexamethylcyclotetrasiloxane on the reproductive organs of male mice. Arch Androl 2(4):371-374.
Albanus L, Bjorklund NE, Gustafsson B, Jonsson M. 1975. Forty days oral toxicity of 2,6-cis-diphenylhexamethylcyclotetrasiloxane (KABI 1774)in beagle dogs with special reference to effects on the male reproductive system. Acta Pharmacol Toxicol (Copenh) 36(Suppl 3):93-130.
Le Vier RR, Boley WF. 1975. The antigonadotropic activity of an organosiloxane in the male rat: 2,6-cis-diphenylhexamethylcyc otetrasiloxane. Acta Pharmacol Toxicol (Copenh) 36(Suppl 3):55-67.
LeVier RR, Jankowiak ME. 1972. The hormonal and antifertility activity of 2,6-cis-diphenyl?hexamethylcyclotetrasiloxane in the female rat. Biol Reprod 7(2):260-266 [republished as Le Vier RR, Jankowiak ME. 1975. The hormonal and antifertility activity of 2,6-cis-diphenylhexa-methylcyclotetrasiloxane in the female rat. Acta Pharmacol Toxicol (Copenh) 36(Suppl 3):81-92].
Nicander L. 1975. Changes produced in the male genital organs of rabbits and dogs by 2,6-cis-diphenylhexamethylcyclotetrasiloxane (KABI 1774). Acta Pharmacol Toxicol (Copenh) 36(Suppl 3):40-54.

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