2-ethylhexyl-4-methoxycinnamate

Synonyms: "octylmethoxycinnamate", "octinoxate", "octyl methoxycinnamate", "parsol", "escalol", "2-ethylhexyl p-methoxycinnamate"

Source: 2-ethylhexyl-4-methoxycinnamate is mainly used in cosmetics.

Identifiers:

IUPAC Name: 2-ethylhexyl (E)-3-(4-methoxyphenyl)prop-2-enoate
CAS Number: 5466-77-3
PubChem ID: 5355130
InChiKey: YBGZDTIWKVFICR-JLHYYAGUSA-N
Canonical SMILES: CCCCC(CC)COC(=O)C=CC1=CC=C(C=C1)OC

Structural Properties:

Molecular Formula: C18H26O3
Molecular Weight: 290.397

Pharmacophore Features:

Number of bond donors: 0
Number of bond acceptors: 2
Number of atoms different from hydrogen: 21

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Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors
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Carbone S, Szwarcfarb B, Reynoso R, Ponzo OJ, Cardoso N, Ale E, Moguilevsky JA, Scacchi P. 2010. In vitro effect of octyl - methoxycinnamate (OMC) on the release of Gn-RH and amino acid neurotransmitters by hypothalamus of adult rats. Exp Clin Endocrinol Diabetes 118(5):298-303.

Klammer H, Schlecht C, Wuttke W, Jarry H. 2005. Multi-organic risk assessment of estrogenic properties of octyl-methoxycinnamate in vivo - A 5-day sub-acute pharmacodynamic study with ovariectomized rats. Toxicology 215(1-2):90-96.

Klammer H, Schlecht C, Wuttke W, Schmutzler C, Gotthardt I, Kohrle J, Jarry H. 2007. Effects of a 5-day treatment with the UV-filter octyl-methoxycinnamate (OMC) on the function of the hypothalamo-pituitary-thyroid function in rats. Toxicology 238(2-3):192-199.

Rachon D, Rimoldi G, Wuttke W. 2006. In vitro effects of benzophenone-2 and octyl-methoxycinnamate on the production of interferon-gamma and interleukin-10 by murine splenocytes. Immunopharmacol Immunotoxicol 28(3):501-510.Seidlova-Wuttke D, Jarry H, Christoffel J, Rimoldi G, Wuttke W. 2006. Comparison of effects of estradiol (E2) with those of octylmethoxycinnamate (OMC) and 4-methylbenzylidene camphor (4MBC)--2 filters of UV light - on several uterine, vaginal and bone parameters. Toxicol Appl Pharmacol 210(3):246-254.

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