Synonyms: "1,2,7,8-TCDF", "PCDF 61"

Source: 1,2,7,8-tetrachlorodibenzofuran is one of the polychlorinated dibenzofurans (PCDFs), which are ubiquitous environmental contaminants, usually formed as byproducts of the production and use of polychlorinated biphenyls (PCBs).


IUPAC Name: 1,2,7,8-tetrachlorodibenzofuran
CAS Number: 58802-20-3
PubChem ID: 42844
Canonical SMILES: C1=CC(=C(C2=C1OC3=CC(=C(C=C32)Cl)Cl)Cl)Cl

Structural Properties:

Molecular Formula: C12H4Cl4O
Molecular Weight: 305,972

Pharmacophore Features:

Number of bond donors: 0
Number of bond acceptors: 0
Number of atoms different from hydrogen: 17


2D structure (.sdf)
3D structure (.sdf)
3D structure (.mol2)
3D structure (.pdb)
3D structure (.pdbqt)

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Toxicological Information

ACToR (Aggregated Computational Toxicology Resource)

CTD (Comparative Toxicogenomics Database)

Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors

Harper N, Wang X, Liu H, Safe S. 1994. Inhibition of estrogen-induced progesterone receptor in MCF-7 human breast cancer cells by aryl hydrocarbon (Ah) receptor agonists. Molecular & Cellular Endocrinology 104(1):47-55.
Liu H, Biegel L, Narasimhan TR, Rowlands C, Safe S. 1992. Inhibition of insulin-like growth factor-I responses in MCF-7 cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Mol Cell Endocrinol 87(1-3):19-28.

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