Synonyms: "3,4,3',4'-tetrachlorobiphenyl", "PCB 77", "4-CB"

Source: 3,3',4,4'-tetrachlorobiphenyl is a member of the polychlorinated biphenyl (PCB), a group of industrial chemicals used as dielectrics, coolants and lubricants in electrical equipment. PCBs contaminate water by leaching from landfills or other waste deposits.


IUPAC Name: 1,2-dichloro-4-(3,4-dichlorophenyl)benzene
CAS Number: 32598-13-3
PubChem ID: 36187
Canonical SMILES: C1=CC(=C(C=C1C2=CC(=C(C=C2)Cl)Cl)Cl)Cl

Structural Properties:

Molecular Formula: C12H6Cl4
Molecular Weight: 291.988

Pharmacophore Features:

Number of bond donors: 0
Number of bond acceptors: 0
Number of atoms different from hydrogen: 16


2D structure (.sdf)
3D structure (.sdf)
3D structure (.mol2)
3D structure (.pdb)
3D structure (.pdbqt)

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Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors

Durham SK, Brouwer A. 1990. 3,4,3',4'-Tetrachlorobiphenyl distribution and induced effects in the rat adrenal gland: Localization in the zona fasciculata. Lab Invest 62(2):232-239.

Schantz SL, Seo B-W, Moshtaghian J, Amin S. 1997. Developmental exposure to polychlorinated biphenyls or dioxin: do changes in thyroid function mediate effects on spatial learning? Am Zool 37(4):399-408.

Van den Berg KJ, van Raaij JAGM, Bragt PC, Notten WRF. 1991. Interactions of halogenated industrial chemicals with transthyretin and effects on thyroid hormone levels in vivo. Arch Toxicol 65(1):15-19.

van den Berg KJ, Zurcher C, Brouwer A. 1988. Effects of 3,4,3',4'-tetrachlorobiphenyl on thyroid function and histology in marmoset monkeys. Toxicol Lett 41(1):77-86.

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