ethylene glycol monomethyl ether

Synonyms: "methyl cellosolve", "2-methoxyethanol", "ethylene glycol monomethyl ether", "methyl oxitol", "2-methoxy-1-ethanol", "monomethyl glycol"

Source: 2-methoxyethanol is used as a jet fuel de-icer. It is also used as a solvent for cellulose acetate, resins, dyes, and quick drying varnishes, enamels, nail polishes and wood stains.

Identifiers:

IUPAC Name: 2-methoxyethanol
CAS Number: 109-86-4
PubChem ID: 8019
InChiKey: XNWFRZJHXBZDAG-UHFFFAOYSA-N
Canonical SMILES: COCCO

Structural Properties:

Molecular Formula: C3H8O2
Molecular Weight: 76.094

Pharmacophore Features:

Number of bond donors: 1
Number of bond acceptors: 2
Number of atoms different from hydrogen: 5

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Evidence Supporting This Chemical as an Endocrine Disruptor
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Creasy DM, Flynn JC, Gray TJ, Butler WH. 1985. A quantitative study of stage specific spermatocyte damage following administration of ethylene glycol monomethyl ether in the rat. Experimental & Molecular Pathology 43(3):321-336.

Linder RE, Strader LF, Slott VL, Suarez JD. 1992. Endpoints of spermatotoxicity in the rat after short duration exposures to fourteen reproductive toxicants. Reprod Toxicol 6(6):491-505.

Nagano K, Nakayama E, Oobayashi H, Nishizawa T, Okuda H, Yamazaki K. 1984. Experimental studies on toxicity of ethylene glycol alkyl ethers in Japan. Environ Health Perspect 57:75-84.

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