Synonyms: "alvit", "dieldrex", "dieldrin"

Source: dieldrin is an insecticide and a by-product of the pesticide Aldrin.


IUPAC Name: (1aR,2R,2aS,3S,6R,6aR,7S,7aS)-3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-2,7:3,6-dimethanonaphtho[2,3-b]oxirene
CAS Number: 60-57-1
PubChem ID: 969491
Canonical SMILES: C1C2C3C(C1C4C2O4)C5(C(=C(C3(C5(Cl)Cl)Cl)Cl)Cl)Cl

Structural Properties:

Molecular Formula: C12H8Cl6O
Molecular Weight: 380,909

Pharmacophore Features:

Number of bond donors: 0
Number of bond acceptors: 1
Number of atoms different from hydrogen: 19


2D structure (.sdf)
3D structure (.sdf)
3D structure (.mol2)
3D structure (.pdb)
3D structure (.pdbqt)

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Toxicological Information

ACToR (Aggregated Computational Toxicology Resource)

HSDB (Hazardous Substances Data Bank)

CCRIS (Chemical Carcinogenesis Research Information System)


CTD (Comparative Toxicogenomics Database)

IRIS (Integrated Risk Information System)

ITER (International Toxicity Estimates for Risk)

Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors

Abalis IM, Eldefrawi ME, Eldefrawi AT. 1985. High-affinity stereospecific binding of cyclodiene insecticides and gamma-hexachlorocyclohexane to gamma-aminobutyric acid receptors of rat brain. Pesticide Biochemistry & Physiology 24(1):95-102.
Danzo BJ. 1997. Environmental xenobiotics may disrupt normal endocrine function by interfering with the binding of physiological ligands to steroid receptors and binding proteins. Environ Health Perspect 105(3):294-301.
Haake J, Kelley M, Keys B, Safe S. 1987. The effects of organochlorine pesticides as inducers of testosterone and benzo[a]pyrene hydroxylases. Gen Pharmacol 18(2):165-169.
Soto AM, Chung KL, Sonnenschein C. 1994. The pesticides endosulfan, toxaphene and dieldrin have estrogenic properties in human estrogen-sensitive cells. Environ Health Perspect 102(4):380-383.
Wassermann M, Wassermann D, Kedar E, Djavaherian M, Cucos S. 1972. Effects of dieldrin and gamma BHC on serum proteins and PBI. Bull Environ Contam Toxicol 8(3):177-185.

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