endrin

Synonyms: "endricol", "mendrin", "nendrin", "oktanex", "stardrin", "endrex"

Source: endrin is an organochloride that was primarily used as an insecticide, as well as a rodenticide .

Identifiers:

IUPAC Name: (1aR,2R,2aR,3R,6S,6aS,7S,7aS)-3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-2,7:3,6-dimethanonaphtho[2,3-b]oxirene
CAS Number: 72-20-8
PubChem ID: 12358480
InChiKey: DFBKLUNHFCTMDC-GKRDHZSOSA-N
Canonical SMILES: C1C2C3C(C1C4C2O4)C5(C(=C(C3(C5(Cl)Cl)Cl)Cl)Cl)Cl

Structural Properties:

Molecular Formula: C₁₂H₈Cl₆O
Molecular Weight: 380.909

Pharmacophore Features:

Number of bond donors: 0
Number of bond acceptors: 1
Number of atoms different from hydrogen: 19

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2D structure (.sdf)
3D structure (.sdf)
3D structure (.mol2)
3D structure (.pdb)
3D structure (.pdbqt)

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Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors

Abalis IM, Eldefrawi ME, Eldefrawi AT. 1985. High-affinity stereospecific binding of cyclodiene insecticides and gamma-hexachlorocyclohexane to gamma-aminobutyric acid receptors of rat brain. Pesticide Biochemistry & Physiology 24(1):95-102.

Chernoff N, Kavlock RJ, Hanisch RC, Whitehouse DA, Gray JA, Gray LE Jr, Sovocool GW. 1979. Perinatal toxicity of endrin in rodents. I. Fetotoxic effects of prenatal exposure in hamsters. Toxicology 13(2):155-165.

Good EE, Ware GW. 1969. Effects of insecticides on reproduction in the laboratory mouse. IV. Endrin and dieldrin. Toxicol Appl Pharmacol 14(1):201-203.

Grant BF, Mehrle PM. 1975. Endrin toxicosis in rainbow trout (Salmo gairdneri). Journal of the Fisheries Research Board of Canada 30(1):31-40.

Kojima H, Katsura E, Takeuchi S, Niiyama K, Kobayashi K. 2004. Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ Health Perspect 112(5):524-531.