dibutyl phthalate

Synonyms: "di-n-butyl phthalate", "n-butyl phthalate", "butyl phthalate", "celluflex DPB", "elaol", "genoplast B", "palatinol C", "polycizer DBP"

Source: dibutyl phthalate is used in making flexible plastics that are found in a variety of consumer products. It is used mainly in nail products as a solvent for dyes and as a plasticizer that prevents nail polishes from becoming brittle.

Identifiers:

IUPAC Name: dibutyl benzene-1,2-dicarboxylate
CAS Number: 84-74-2
PubChem ID: 3026
InChiKey: DOIRQSBPFJWKBE-UHFFFAOYSA-N
Canonical SMILES: CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC

Structural Properties:

Molecular Formula: C16H22O4
Molecular Weight: 278,3435

Pharmacophore Features:

Number of bond donors: 0
Number of bond acceptors: 2
Number of atoms different from hydrogen: 20

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Toxicological Information

ACToR (Aggregated Computational Toxicology Resource)

HSDB (Hazardous Substances Data Bank)

CCRIS (Chemical Carcinogenesis Research Information System)

GENE-TOX

CTD (Comparative Toxicogenomics Database)

IRIS (Integrated Risk Information System)

ITER (International Toxicity Estimates for Risk)

Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors


Davis WP. 1988. Reproductive and developmental responses in the self-fertilizing fish, Rivulus marmoratus, induced by the plasticizer, di-n-butylphthalate. Environmental Biology of Fishes 21(2):81-90.
Fan WQ, Yanase T, Morinaga H, Gondo S, Okabe T, Nomura M, Komatsu T, Morohashi K-I, Hayes TB, Takayanagi R, Nawata H. 2007. Atrazine-induced aromatase expression is SF-1 dependent: implications for endocrine disruption in wildlife and reproductive cancers in humans. Environ Health Perspect 115(5):720-727.
Kanayama T, Kobayashi N, Mamiya S, Nakanishi T, Nishikawa J. 2005. Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor [gamma]/retinoid X receptor pathway. Mol Pharmacol 67(3):766-774.
Lu KY, Tseng FW, Wu CJ, Liu PS. 2004. Suppression by phthalates of the calcium signaling of human nicotinic acetylcholine receptors in human neuroblastoma SH-SY5Y cells. Toxicology 200(2-3):113-121.
Ryu JY, Lee BM, Kacew S, Kim HS. 2007. Identification of differentially expressed genes in the testis of Sprague-Dawley rats treated with di(n-butyl) phthalate. Toxicology 234(1-2):103-112.

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Keywords


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