triclosan

Synonyms: "5-chloro-2-(2,4-dichlorophenoxy)phenol", "cloxifenolum", "triclosanum", "irgasan", "2,4,4'-trichloro-2'-hydroxydiphenyl ether"

Source: triclosan is an ingredient added to many consumer products to reduce or prevent bacterial contamination. It may be found in products such as clothing, kitchenware, furniture, and toys. It also may be added to antibacterial soaps and body washes, toothpastes, and some cosmetics.

Identifiers:

IUPAC Name: 5-chloro-2-(2,4-dichlorophenoxy)phenol
CAS Number: 3380-34-5
PubChem ID: 5564
InChiKey: XEFQLINVKFYRCS-UHFFFAOYSA-N
Canonical SMILES: C1=CC(=C(C=C1Cl)O)OC2=C(C=C(C=C2)Cl)Cl

Structural Properties:

Molecular Formula: C₁₂H₇Cl₃O₂
Molecular Weight: 289.542

Pharmacophore Features:

Number of bond donors: 1
Number of bond acceptors: 1
Number of atoms different from hydrogen: 17

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2D structure (.sdf)
3D structure (.sdf)
3D structure (.mol2)
3D structure (.pdb)
3D structure (.pdbqt)

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Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors

Ahn KC, Zhao B, Chen J, Cherednichenko G, Sanmarti E, Denison MS, Lasley B, Pessah IN, Kultz D, Chang DPY, Gee SJ, Hammock BD. 2008. In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: Receptor-based bioassay screens. Environ Health Perspect 116(9):1203-1210.

Zorrilla LM, Gibson EK, Jeffay SC, Crofton KM, Setzer WR, Cooper RL, Stoker TE. 2009. The effects of triclosan on puberty and thyroid hormones in male Wistar rats. Toxicol Sci 107(1):56-64.