amitrole

Synonyms: "3-amino-1,2,4-triazole", "aminotriazole", "amitrol", "1H-1,2,4-triazol-3-amine", "amerol", "amizol", "emisol", "vorox"

Source: amitrole is a terrestrial non-food herbicide used primarily in industrial areas (outdoors), non-agricultural rights-of-way, fencerows, hedgerows, non-agricultural uncultivated areas, soils, ornamental and/or shade trees, and ornamental shrubs and vines.

Identifiers:

IUPAC Name: 1H-1,2,4-triazol-5-amine
CAS Number: 61-82-5
PubChem ID: 1639
InChiKey: KLSJWNVTNUYHDU-UHFFFAOYSA-N
Canonical SMILES: C1=NNC(=N1)N

Structural Properties:

Molecular Formula: C₂H₄N₄
Molecular Weight: 84.080

Pharmacophore Features:

Number of bond donors: 2
Number of bond acceptors: 3
Number of atoms different from hydrogen: 6

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Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors

Fregly MJ. 1968. Effect of aminotriazole on thyroid function in the rat. Toxicol Appl Pharmacol 13(3):271-286.

Hurley PM, Hill RN, Whiting RJ. 1998. Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents [review]. Environ Health Perspect 106(8):437-445.

Jukes TH, Shaffer CB. 1960. Antithyroid effects of aminotriazole. Science 132(3422):296-297.

Steinhoff D, Weber H, Mohr U, Boehme K. 1983. Evaluation of amitrole (aminotriazole) for potential carcinogenicity in orally dosed rats, mice, and golden hamsters. Toxicol Appl Pharmacol 69(2):161-169.