aldicarb

Synonyms: "temik", "aldicarbe", "carbamyl", "sulfone aldoxycarb"

Source: aldicarb is a multi-use pesticide that controls populations of agriculturally-harmful insects and nematodes.

Identifiers:

IUPAC Name: [(E)-(2-methyl-2-methylsulfanylpropylidene)amino] N-methylcarbamate
CAS Number: 116-06-3
PubChem ID: 9570071
InChiKey: QGLZXHRNAYXIBU-WEVVVXLNSA-N
Canonical SMILES: CC(C)(C=NOC(=O)NC)SC

Structural Properties:

Molecular Formula: C7H14N2O2S
Molecular Weight: 190,263

Pharmacophore Features:

Number of bond donors: 1
Number of bond acceptors: 3
Number of atoms different from hydrogen: 12

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Toxicological Information

ACToR (Aggregated Computational Toxicology Resource)

HSDB (Hazardous Substances Data Bank)

CCRIS (Chemical Carcinogenesis Research Information System)

GENE-TOX

CTD (Comparative Toxicogenomics Database)

IRIS (Integrated Risk Information System)

ITER (International Toxicity Estimates for Risk)

Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors


Casale GP, Vennerstrom JL, Bavari S, Wang T. 1993. Inhibition of interleukin 2 driven proliferation of mouse CTLL2 cells, by selected carbamate and organophosphate insecticides and congeners of carbaryl. Immunopharmacology & Immunotoxicology 15(2 & 3):199-215.
Hajoui O, Flipo D, Mansour S, Fournier M, Krzystyniak K. 1992. Immunotoxicity of subchronic versus chronic exposure to aldicarb in mice. Int J Immunopharmacol 14(7):1203-1211.
Kanayama T, Kobayashi N, Mamiya S, Nakanishi T, Nishikawa J. 2005. Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor [gamma]/retinoid X receptor pathway. Mol Pharmacol 67(3):766-774.
Klotz DM, Arnold SF, McLachlan JA. 1997. Inhibition of 17 beta-estradiol and progesterone activity in human breast and endometrial cancer cells by carbamate insecticides. Life Sci 60(17):1467-1475.
Smulders CJ, Bueters TJ, Van Kleef RG, Vijverberg HP. 2003. Selective effects of carbamate pesticides on rat neuronal nicotinic acetylcholine receptors and rat brain acetylcholinesterase. Toxicol Appl Pharmacol 193(2):139-146.

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