alachlor

Synonyms: "lasagrin", "metachlor", "methachlor", "alanex", "lasso", "alapaz", "alachlore", "alochlor", "chimiclor"

Source: alachlor is a herbicide from the chloroacetanilide family.

Identifiers:

IUPAC Name: 2-chloro-N-(2,6-diethylphenyl)-N-(methoxymethyl)acetamide
CAS Number: 15972-60-8
PubChem ID: 2078
InChiKey: XCSGPAVHZFQHGE-UHFFFAOYSA-N
Canonical SMILES: CCC1=C(C(=CC=C1)CC)N(COC)C(=O)CCl

Structural Properties:

Molecular Formula: C14H20ClNO2
Molecular Weight: 269,767

Pharmacophore Features:

Number of bond donors: 0
Number of bond acceptors: 2
Number of atoms different from hydrogen: 18

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Toxicological Information

ACToR (Aggregated Computational Toxicology Resource)

HSDB (Hazardous Substances Data Bank)

CCRIS (Chemical Carcinogenesis Research Information System)

GENE-TOX

CTD (Comparative Toxicogenomics Database)

IRIS (Integrated Risk Information System)

ITER (International Toxicity Estimates for Risk)

Evidence Supporting This Chemical as an Endocrine Disruptor
TEDX List of Potential Endocrine Disruptors


Klotz DM, Beckman BS, Hill SM, McLachlan JA, Walters MR, Arnold SF. 1996. Identification of environmental chemicals with estrogenic activity using a combination of in vitro assays. Environ Health Perspect 104(10):1084-1089.
Kojima H, Katsura E, Takeuchi S, Niiyama K, Kobayashi K. 2004. Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ Health Perspect 112(5):524-531.
Lemaire G, Mnif W, Pascussi JM, Pillon A, Rabenoelina F, Fenet H, Gomez E, Casellas C, Nicolas JC, Cavailles V, Duchesne MJ, Balaguer P. 2006. Identification of new human pregnane X receptor ligands among pesticides using a stable reporter cell system. Toxicol Sci 91(2):501-509.
Scippo ML, Argiris C, Van De Weerdt C, Muller M, Willemsen P, Martial J, Maghuin-Rogister G. 2004. Recombinant human estrogen, androgen and progesterone receptors for detection of potential endocrine disruptors. Anal Bioanal Chem 378(3):664-669.
Wilson AGE, Thake DC, Heydens WE, Brewster DW, Hotz KJ. 1996. Mode of action of thyroid tumor formation in the male Long-Evans rat administered high doses of alachlor. Fundam Appl Toxicol 33(1):16-23.

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